![]() ![]() ![]() Improvements in the biocompatibility of stent designs could reduce stent-associated thrombosis and in-stent restenosis. Objective Neointimal hyperplasia is a major complication of endovascular stent placement with consequent in-stent restenosis or occlusion. Kim, J H Shin, J H Shin, D H Moon, M-W Park, K Kim, T-H Shin, K M Won, Y H Han, D K Lee, K-R These findings demonstrate the potential for the coatings to aid in the prevention of restenosis and sets up future explorations of ex vivo and in vivo studies.Ĭomparison of diamond-like carbon- coated nitinol stents with or without polyethylene glycol grafting and uncoated nitinol stents in a canine iliac artery model I will also demonstrate the synthesis of a nanowell coating on Nitinol stents as well as an additional poly(lactic-co-glycolic acid) coating on top of the nanowells that has the potential for controlling drug release. The coating also reduced the proliferation and mRNA expression of collagen I and MMP2 for primary human aortic smooth muscle cells. Certain cellular functions such as collagen and elastin production were also found to be affected by changes in nanotube diameter. I found that the coating demonstrated 'pro-healing' properties by increasing primary human aortic endothelial cell spreading, migration and collagen and elastin production. ![]() Here, I present my study on the synthesis and characterization of a nanotubular coating on Nitinol substrates. Nitinol-based Nanotubular and Nanowell Coatings for the Modulation of Human Vascular Cell FunctionsĬurrent approaches to reducing restenosis do not balance the reduction of vascular smooth muscle cell proliferation with the increase in the healing of the endothelium. ![]()
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